A. Substantial Shareholder
Holders of substantial holdings of ordinary shares in the Company and the number of shares in which they and their associates have a relevant interest as at 31 August 2015:
| Shareholder | Number of ordinary shares held |
| Professor Silviu Itescu | 68,244,642 |
| Cephalon, Inc. | 55,785,806 |
| M&G Investment Group | 38,717,697 |
| The Capital Group Companies, Inc. | 26,600,000 |
| Thorney Opportunities Ltd | 19,004,000 |
B. Twenty Largest Holders of Quoted Securities
The names of the 20 largest shareholders of each class of equity security as at 31 August 2015 are listed below:
| Rank | Shareholder | No. of shares held | % of total shares |
| 1 | HSBC Custody Nominees (Australia) Ltd | 98,954,258 | 29.34% |
| 2 | Professor Silviu Itescu | 67,751,838 | 20.09% |
| 3 | Cephalon, Inc. | 55,785,806 | 16.54% |
| 4 | National Nominees Limited | 20,382,834 | 6.04% |
| 5 | Celgene Alpine Investment Company III, LLC | 15,298,837 | 4.54% |
| 6 | J P Morgan Nominees Australia Limited | 10,052,566 | 2.98% |
| 7 | Dalit Pty Ltd | 4,468,839 | 1.32% |
| 8 | Mesoblast Australia Pty Ltd* | 3,500,000 | 1.04% |
| 9 | BNP Paribas Noms Pty Ltd | 2,229,920 | 0.66% |
| 10 | Citicorp Nominees Pty Limited | 2,043,060 | 0.61% |
| 11 | Adelaide Health Services, Inc. | 1,953,000 | 0.58% |
| 12 | JGM Investment Group Pty Ltd | 1,881,200 | 0.56% |
| 13 | UBS Nominees Pty Ltd | 1,757,986 | 0.52% |
| 14 | Osiris Therapeutics, Inc. | 1,391,178 | 0.41% |
| 15 | Avister Pty Ltd | 1,198,354 | 0.36% |
| 16 | National Nominees Limited | 1,130,750 | 0.34% |
| 17 | Tigcorp Nominees Pty Ltd | 1,060,000 | 0.31% |
| 18 | Michael Spooner | 868,272 | 0.26% |
| 19 | CS Fourth Nominees Pty Ltd | 20,619 | 0.21% |
| 20 | Finarg1 Services Company Ltd | 597,800 | 0.18% |
| 293,027,117 | 86.88% |
*As trustee for the Mesoblast Limited Employee Share Trust, held on behalf of employees who participate in the Company's loan funded share plan.
updated 22nd December, 2015
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